Event Calendar

Lectures & Seminars

06.06.2018 18:00 - 19:00 o'clock


MiCoCo: Learning how to eat, drink and kill microbes with Dictyostelium amoebae

Lecturer: Dr. Jason King, Department of Biomedical Science, The University of Sheffield

We are interested in how phagocytic cells engulf both extracellular microbes and fluid from their environment - processes known as phagocytosis and macropinocytosis respectively. Both involve the spatial regulation of the cytoskeleton in order to generate cup-shaped protrusions to capture their targets, but how this is achieved is poorly understood, particularly in the case of macropinosomes which self-assemble without any localised extracellular signalling. Using Dictyostelium amoebae that live in soil, eating bacteria, we describe a new mechanism by which the cytoskeleton is organised during cup formation, and show that this is required for both normal macropinosome formation, as well enabling phagocytes to eat microbes of diverse shapes.

After engulfment, phagosomes and macropinosomes must be efficiently processed in order to kill and digest potential pathogens before infection can be established, as well as liberate nutrients to support growth. I will also describe our recent work on maturation, and how phosphoinositide signalling via the lipid kinase PIKfyve mediates the delivery of delivery of key phagosomal components to enhance bacterial killing and suppress infection by Legionella.

Date: June 6, 2018

Time: 6 pm

Location: Lecture Hall Erbertstraße (Großer Hörsaal)

All interested are cordially invited!

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