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Lectures & Seminars

08.11.2017 18:00 - 19:00 o'clock


MiCoCo: Genome Mining in Pseudomonads- A Journey from their Genomes to Secondary Metabolites and back

Lecturer: Prof Dr. Harald Groß, Pharmaceutical Institute, Department of Pharmaceutical Biology, University of Tuebingen

Abstract:

Pseudomonas is a diverse genus of Gammaproteobacteria with more than 60 species exhibiting varied life styles in a wide range of environments, including soil, water, plant surfaces, and animals. They are well known for their ubiquity in the natural world, capacity to utilize a striking variety of organic compounds as energy sources, resistance to a wide range of antibiotics, and for the production of a remarkable array of medically- and agriculturally-important secondary metabolites. Some compounds are even in clinical use, such as the topical antibiotic mupirocin (Bactroban®) which is used for dermal infections with methicillin-resistant Staphylococcus aureus (MRSA). Through the vast number of sequencing projects it became evident that the genus Pseudomonas has a tremendous capacity to assemble exciting metabolites using intriguing biochemistry.

Illustrated by examples, the recent efforts and contributions of the Gross group to the field of genome mining in Pseudomonads for new bioactive natural products will be outlined. The journey starts from bioinformatic analyses and predictions applied to whole genome sequences of Pseudomonas bacteria which led e.g. to the discovery of novel lipopeptides, such as orfamides and poaeamides. In order to overcome silent gene cluster, a regulator activation strategy tool will be presented. Last not least, the intriguing biosynthetic machinery of Pseudomonads which can be both, extremely simple but also very complex, will be highlighted by taking a closer look at the biosynthesis of the unique bicyclic carbamate brabantamide and the fatty acid-derived pseudopyronines, respectively.

Date: November 8th 2017

Time: 6 pm

Location: Lecture Hall Erbertstraße (Großer Hörsaal)

All interested are cordially invited!

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