Doctoral Researchers

 
Gallegos Monterrosa, Ramses

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Institute/Dep.
Friedrich Schiller University Jena
Institute of Microbiology
Junior Research Group Terrestrial Biofilms
PhD Project:

Cell-cell communication in single species and mixed biofilms

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Abstract: Background Biofilm formation costs and benefits the society. On one hand biofilms can be negative, for example, biofilms are a source of contamination in food processing equipment,...
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... can reduce heat transfer in cooling towers, increase drag on ships, foul reverse osmosis membranes and even corrode metal surfaces; moreover, since biofilms have great resistance to antimicrobial treatment, they are difficult to control in industry or the clinic. On the other hand, biofilms can be also beneficial, such as in the case of biofilm formation by Bacillus subtilis in various crop plant root systems. In most cases biofilm formation has been targeted (to prevent or to promote) by altering the ability of bacteria to attach itself to surfaces or by changing pathways involved in matrix production. Aim The current project is involved in the cell-cell communication (i.e. quorum sensing) in single- and multi-species biofilms. The role of various B. subtilis produced quorum sensing molecules will be examined during biofilm formation. Further, the role of various global transcription regulators will be examined in a novel approach based on random mutagenesis to identify the important features of these regulators during biofilm development and in quorum sensing. Finally, the current project aims to get a better insight into quorum sensing through the use of mixed species biofilms and reveal the effect that different Bacillus species may have over the development of B. subtilis biofilms. The different parts of this project will all aim to characterize and identify possible targeting of quorum sensing in bacterial biofilms that could be further exploited in medical or biotechnological settings.
 
 
Garbe, Enrico

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Institute/Dep.
Leibniz Institute for Natural Product Research and Infection Biology - Hans Knöll Institute (HKI)
Junior Research Group Host Fungal Interfaces
PhD Project:

Transcriptional control of environmental pH modulation in the fungal pathogen Candida albicans

 
 
Gore, Sagar

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ChemBioSys Student

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Institute/Dep.
Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute-
Research Group: Systems Biology / Bioinformatics
PhD Project:

Pattern recognition methods for prediction of chemical structure of fungal secondary metabolites