Doctoral Researchers

 
Jo, Emeraldo

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Institute/Dep.
Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institute-
Research Group:
Infection Biology
PhD Project:

Mechanisms of adhesion and modulation of human immune cells by Candida albicans

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Abstract: The human pathogenic yeast Candida albicans (C. albicans) responds and inhibits host innate as well as adaptive immune reactions. This project aims at elucidating the mechanisms of...
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... immune responses by human monocytes and macrophages to C. albicans. Novel microbial proteins will be defined that alone or together with recruited human plasma proteins modulate opsonizastion and cell interaction. Complement cleavage products are the natural ligands of complement receptors CR3 and CR4 expressed on human monocytes and macrophages. The characterization of the molecular and the cellular interplay, on the level of single molecules and cells, will be carried out and developed into a bioinformatics-based infection model, that will offer novel theapeutic targets for treatment.
 
 
Institute/Dep.
Leibniz Institute of Photonic Technology (IPHT)
Dep. of Microscopy
PhD Project:

Development and application of high spatial resolution imaging for the characterization of intracellular infections