Doctoral Researchers

 
Normann, Nicole

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Institute/Dep.
PhD Project:

Protein markers for pathogen detection and risk stratification in patients with a suspected bacterial infection

 
 
Novohradská, Silvia

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JSMC Fellow

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Institute/Dep.
Leibniz Institute for Natural Product Research and Infection Biology - Hans-Knöll-Institut
Junior Research Group Evolution of Microbial Interactions
PhD Project:

Soil amoeba interactions with filamentous fungi as driving forces for pathogenicity

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Abstract: The filamentous fungus Aspergillus fumigatus is a well described example of an environmentally acquired pathogen. The colonization of the host organism is based on the multifactorial...
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... virulence mechanisms, which may have emerged long before the appearance of innate immune systems and could at least partially result from the selection pressure imposed by amoeba predation (Seaton and Robertson, 1989; Casadevall, 2012). Our central question is therefore how the interaction with predatory amoeba could also have stimulated the development of virulence mechanisms? Where did the fungus "learn" to cope with the residual innate immune responses and has acquired the abilities necessary for an invasive host colonization? Why some fungi use such highly structured mycotoxins which seem to target a wide range of cellular process in vertebrates? References Seaton A, Robertson MD (1989) Aspergillus, asthma, and amoebae. Lancet 1:893-4. Casadevall A (2012) Amoeba provide insight into the origin of virulence in pathogenic fungi. Adv Exp Med Biol 710:1-10